After 32 seconds, the 22-year-old Serb, a £58m transfer from Fiorentina last month, sprinted onto Danilo’s long pass before a turn and precise finish.
Giovani lo Celso of Villarreal sliced a shot off the outside of the post.
Dani Parejo finished off Etienne Capoue’s acrobatic pass into the area to bring the game level.
Adrien Rabiot was only booked for a reckless tackle on Samuel Chukwueze; thus, Juventus were fortunate to finish with 11 men.
“However, I am not completely satisfied because we did not win the game. Personally, I’ve already forgotten about this game and am looking forward to the next”.
The tie is equal heading into the second leg in Turin in three weeks, thanks to the elimination of the away goal rule this year.
Juventus have been undefeated in 90 minutes since November, but they were punished at Estadio de la Ceramica for their hostility.